Senior Software Engineer & Project Lead, Biology

POSITION SUMMARY The Center for Computational Biology is seeking an experienced software engineer to be the Project Lead for HumanBase (hb.flatironinstitute.org), a dynamic and interactive web-based platform that supports thousands of biomedical researchers in exploring the molecular mechanisms of human disease. This position is ideal for an experienced engineering leader with bioinformatics experience who thrives on solving complex problems at the intersection of large-scale data, advanced analytics, and scientific discovery. This is a high-impact role that directly advances the study of human genomics and disease. The successful candidate will lead technical direction and execution, guide other software engineers, and collaborate closely with researchers at the Center for Computational Biology to translate cutting-edge computational biology into robust software tools. The Project Lead will be a hands-on engineering leader with experience in biological data and -omics technology, as well as a complementary skillset that includes both writing high-quality code and managing a small team of software engineers. Success in this role depends on the ability to translate biological questions into computational solutions, collaborate closely with internal scientific stakeholders, and drive technically rigorous projects that advance our understanding of human biology. ESSENTIAL FUNCT [... source excerpt omitted ...] ode, efficient workflows, and continuous professional development Plan, develop, and optimize scalable genomics data processing pipelines Integrate machine learning methods into production pipelines to analyze heterogeneous biological datasets Establish and enforce software engineering best practices, including coding standards, version control, documentation, testing, and deployment workflows Collaborate cross-functionally with computational biologists, data scientists, and external partners to align engineering efforts with scientific goals Stay current with emerging technologies in cloud infrastructure, bioinformatics, and scientific computing and assess their relevance for [... source excerpt omitted ...] ing software in support of biological research Experience working with large, heterogeneous biological datasets—ideally in genomics or biomedical contexts Related Skills & Other Requirements Effective technical leadership and mentorship abilities Excellent communication skills, especially when working across disciplinary boundaries Deep curiosity about science and a passion for building tools that empower scientific discovery Strong sense of ownership and drive for continuous improvement COMPENSATION The range for full-time annual compensation for this position is $190,000-$235,000 based on experience. In addition to competitive salaries, the Simons Foundation provides emplo