> AI agents: this is one page of Nextmove’s FDE site, in Markdown. Nextmove is a job board and free career service for forward deployed engineers (FDEs). Each posting is classified from its text, not its title: the kind of work, how much of it is production code, pre-sales weight, time at customer sites, travel, remote arrangement, level and posted base pay. The site also publishes the aggregates: median pay by level, metro, company and kind of work, and which companies started hiring FDEs each week. Every page under https://nextmove.md/fde is served this way; the index of pages is https://nextmove.md/llms.txt.

# Principal Full Stack AI Engineer

Canonical URL: https://nextmove.md/fde/jobs/3d554cffe1ee5e18

Vertex Pharmaceuticals posts a principal FDE role to build for teams inside the company in Boston, MA, at $166,640–$250,000 base, below the staff+ FDE median of $225,000 across 388 postings with pay. Vertex is hiring a Principal Agent Engineer to design, prototype, and productionize AI agents and multi-step agent workflows integrated with enterprise systems and digital products. Read from the employer’s posting on November 9, 2026.

- [Vertex Pharmaceuticals](https://nextmove.md/fde/companies/vertex-pharmaceuticals)

First seen Jul 31, 2026 · open on Workday as of Nov 9, 2026

**$166,640–$250,000** Boston, MA Hybrid Full-time

Vertex is hiring a Principal Agent Engineer to design, prototype, and productionize AI agents and multi-step agent workflows integrated with enterprise systems and digital products.

- [See roles that fit me](https://nextmove.md/sign-up?from=%2Ffde%2Fjobs%2F3d554cffe1ee5e18&placement=top)
- [View posting at Vertex Pharmaceuticals](https://vrtx.wd501.myworkdayjobs.com/vertex_careers/job/Boston-MA/Principal-Agent-Engineer--AI-Agentic-Platform_REQ-29761)

Free. Upload your resume once, see why each FDE role fits, and get introduced only when you say so.

## At a glance

### Posted base pay

$167K–$250K Below the median

Midpoint $208K · median $225K

This job $167K to $250K. Staff+ FDE postings, 388 postings: the middle 50% of posted pay is $197K to $262K, median $225K.

### The work

Builds for teams inside the company

Balance **Mostly building**

Project stages

1. Pre-sales (not covered)
2. Proof of concept
3. Implementation
4. Operations

- **Coding**: Writes production code

- **Builds for**: Both

- **Level**: Staff+

- **Role**: Individual contributor

### Do you meet what the posting states?

The posting reads as a staff-level role. What level are you at now?

The job is in Boston, MA. Could you work there?

Which of these have you used in production?

Answer each one. Nothing is saved or sent.

[What postings ask for, by background →](https://nextmove.md/fde/paths)

## Conditions

- **Location**: Boston, MA

- **Work arrangement**: Hybrid

- **Remote work restrictions**: Hybrid: up to two days remote per week; On-Site: five days on-site with ad hoc flexibility.

- **Employment type**: Full-time

- **Pay**:

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## The job description from Vertex Pharmaceuticals

### Job Description

### Position Summary

Vertex is seeking an Agent Engineer, Agentic AI Platform to help create the next generation of AI agents that deliver practical value across internal and user-facing experiences. This role will focus on prototyping, building, and productionizing multi-step agent workflows that are deeply integrated with enterprise systems, business processes, and digital products.

The ideal candidate is energized by fast-moving AI technology but grounded in strong engineering discipline. This individual will use a forward deployed engineering mindset to work closely with stakeholders, rapidly iterate on real-world use cases, connect agents to APIs and business systems, and continuously improve quality through measurement and feedback. The Agent Engineer will play an important role in shaping how AI agents are adopted and used day to day across Vertex.

### Key Responsibilities

- Design, prototype, and productionize AI agents and multi-step agent workflows for internal and user-facing use cases
- Apply a forward deployed engineering approach by working closely with end users, product teams, and business stakeholders to solve real workflow problems quickly and effectively
- Build agents that can reason across steps, invoke tools, call APIs, retrieve information, and take actions within defined enterprise guardrails
- Integrate agents with internal platforms, third-party applications, enterprise APIs, and business-critical systems
- Develop reusable agent patterns, components, prompts, tools, and orchestration logic that can be scaled across use cases
- Rapidly iterate on agent behavior based on usage data, qualitative feedback, evaluation results, and operational metrics
- Improve agent quality through testing, experimentation, benchmarking, and structured measurement of outcomes
- Partner with platform, integration, data, security, and product teams to ensure agents are secure, reliable, maintainable, and aligned with enterprise architecture
- Help define best practices for agent design, tool use, fallback behavior, escalation paths, and human-in-the-loop workflows
- Support deployment, monitoring, troubleshooting, and optimization of agents in production environments
- Contribute to observability practices for agent execution, including logging, tracing, performance tracking, and issue analysis
- Ensure solutions are designed with security, compliance, and responsible AI principles in mind
- Stay current on emerging patterns, frameworks, and technologies in generative AI and agentic systems, and translate them into practical applications for Vertex

### Required Qualifications

- Bachelor’s degree in Computer Science, Software Engineering, Artificial Intelligence, Data Science, or a related technical field; equivalent practical experience may be considered
- Experience in software engineering, AI engineering, machine learning engineering, or intelligent application development
- Hands-on experience building applications powered by large language models, AI workflows, or agentic systems
- Experience integrating software applications with APIs, data sources, and enterprise systems
- Demonstrated experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems.
- Deep understanding of AI-native software engineering practices and experience establishing standards, governance, and best practices for the responsible use of AI coding assistants and software engineering agents across engineering teams
- Demonstrated ability to move from prototype to production while balancing speed, quality, and operational rigor
- Experience working directly with users or stakeholders to iteratively refine technical solutions based on real-world needs
- Strong problem-solving and systems-thinking skills
- Strong written and verbal communication skills with the ability to work effectively across technical and non-technical teams

### Technical Skills Required

- Large language model application development
- Agentic workflow design and orchestration
- Prompt engineering and prompt iteration
- Tool use and API integration for AI agents
- Multi-step workflow automation
- Rapid prototyping and productionization
- Evaluation, testing, and quality measurement for AI systems
- Application logging, monitoring, and observability
- Distributed systems and service integration
- Secure software development practices
- Enterprise application integration
- Cloud-based application development
- Version control, CI/CD, and deployment practices

### Preferred Skills

- Experience using a forward deployed engineering or similar embedded delivery model
- Experience building internal copilots, assistants, or task-oriented AI agents
- Familiarity with orchestration frameworks, agent runtimes, tool-calling architectures, and retrieval patterns
- Experience integrating with enterprise collaboration tools, workflow systems, document platforms, or knowledge repositories
- Familiarity with evaluation frameworks for AI quality, groundedness, task completion, and reliability
- Experience designing human-in-the-loop workflows and safe failure or escalation mechanisms
- Exposure to AI observability, tracing, and operational analytics
- Experience in regulated industries such as biotechnology, pharmaceuticals, healthcare, or life sciences

#LI-HYBRID

### Pay Range

$166,640 - $250,000

### Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

### Flex Designation

Hybrid-Eligible Or On-Site Eligible

### Flex Eligibility Status

In this Hybrid-Eligible role, you can choose to be designated as:
1. **Hybrid**: work remotely up to two days per week; **or select**
2. **On-Site**: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

### Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

[View posting at Vertex Pharmaceuticals](https://vrtx.wd501.myworkdayjobs.com/vertex_careers/job/Boston-MA/Principal-Agent-Engineer--AI-Agentic-Platform_REQ-29761)

## About Vertex Pharmaceuticals

Biotech that dominates cystic fibrosis treatment and is expanding into non-opioid pain, CRISPR gene therapy for sickle cell, and cell therapy for type-1 diabetes.

Public · 5000+ people

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